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| Dr. Bassam Ali | | | Associate Professor | | Department of Pathology | | | Phone: | 971 3 7137 470 | | Fax: | 971 3 7671966 | | Email: | |
| Degree | University | Year | | PhD | University of Cambridge/UK | 1993 | | MSc | Yarmouk University/Jordan | 1989 | | BSc | Yarmouk University/Jordan | 1986 |
| | Postgraduate Diplomas, Certificates, and Fellowships | Year | | Postgraduate Certificate of Advanced Studies in Learning and Teaching | 2004 | | Fellowship of UK Higher Education Academy | 2007 |
| | Appointment | Year | | Associate Professor, FMHS | 2006-present | | Postdoctoral Research Fellow RAII, Imperial College London | 1999-2005 | | Postdoctoral Research Fellow RAI, Imperial College London | 1997-1999 | | Postdoctoral Research Fellow RAI, University College London | 1995-1997 |
| | Research Interests | -
Identification of the molecular defects underlying genetic disorders in Arab populations.
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Developing molecular diagnostic for genetic diseases found in UAE and Arab populations.
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Elucidation of the Cellular mechanisms underlying human genetic disorders.
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| | Relevant Publications | Hume AN, Buttgereit J, Al-Awadhi AM, Al-Suwaidi SS, John A, Bader M, Seabra MC, Al-Gazali L and Ali BR (2009) Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux. Human Molecular Genetics, 18, 267-277.
Al-Gazali L, Shather B, Kaplan W, Algawi K and Ali BR (2009) Anterior segment anomalies of the eye, growth retardation associated with hypoplastic pituitary gland and endocrine abnormalities: Jung syndrome or a new syndrome? American Journal of Medical Genetics A, 149A, 251-256.
Abdulrazzaq YM, Ibrahim A, Al-Khayat AI, Nagelkerke N and Ali BR (2009) R58fs Mutation in the HGD Gene in a Family with Alkaptonuria in the UAE. Annals of Human Genetics, 73, 125-130.
Ali BR (2009) Is cystic fibrosis-related diabetes an apoptotic consequence of ER stress in pancreatic cells? Medical Hypotheses, 72, 55-57.
Cantagrel V, Silhavy JL, Bielas SL, Swistun D, Marsh SE, Bertrand JY, Audollent S, Attié-Bitach T, Holden KR, Dobyns WB, Traver D, Al-Gazali L, Ali BR, Lindner TH, Caspary T, Otto EA, Hildebrandt F, Glass IA, Logan CV, Johnson CA, Bennett C, Brancati F; International Joubert Syndrome Related Disorders Study Group, Valente EM, Woods CG and Gleeson JG (2008) Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome. American Journal of Human Genetics, 83, 170-179.
Ali BR, Jeffery S, Patel N, Tinworth LE, Meguid N, Patton MA and Afzal AR (2007) Novel Robinow syndrome causing mutations in the proximal region of the frizzled-like domain of ROR2 are retained in the endoplasmic reticulum. Human Genetics, 122, 389-395.
Leung, KF, Baron, R, Ali, BR, Magee, AI and Seabra, MC (2007) Rab GTPases containing a CAAX motif are processed post-geranylgeranylation by proteolysis and methylation. Journal of Biological Chemistry, 282, 1487-1497.
Chen Y, Bellamy WP, Seabra MC, Field MC, Ali BR (2005) ER-associated protein degradation is a common mechanism underpinning numerous monogenic diseases including Robinow syndrome. Hum. Molecular Genetics, 14:2559-2569. |
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