Dr. Farah Mustafa       
       
Assistant Professor
Department of Biochemistry
Phone: 971 3 7137 509
Fax: 971 3 7672033
Email: fmustafa@uaeu.ac.ae


College of Medicine and Health Sciences

United Arab Emirates University
P.O.Box 17666, Al-Ain
United Arab Emirates
DegreeUniversityYear
Ph.DMolecular Genetics and Microbiology; 1993 University of Massachusetts Medical Center, Worcester, MA USA1993
B.Sc. (Hon.)Microbiology; 1987 University of Maryland, College Park, MD USA 1987
AppointmentYear
Postdoctoral Research Associate
Department of Pathology,
University of Massachusetts Medical Center, Worcester, MA USA
Jan. 1993-May 1995
Postdoctoral Research Fellow
Department of Microbiology,
The University of Texas at Austin, Austin, TX USA
March 1996-Aug. 2000
Research Associate
Section of Molecular Genetics and Microbiology,
The University of Texas at Austin, Austin, TX USA
Aug. 2000-Aug. 2001
Lecturer
School of Biological Sciences,
The University of Texas at Austin, Austin, TX USA
Aug. 2000-Aug. 2001
Research Associate
Department of Microbiology,
FMHS, UAE University, Al Ain, UAE
FMHS, UAE University, Al Ain, UAE
Assistant Professor
Department of Biochemistry,
FMHS, UAE University, Al Ain, UAE
May 2005-May 2007
HEC Foreign Professor
Department of Biosciences
COMSATS Information of Information Technology, Islamabad, Pakistan
Aug 2007-Aug 2011
Research Interest
Overall, my research interest lies in the area of molecular basis of diseases induced by retroviruses. These single stranded RNA viruses are well-known pathogens that cause debilitating diseases such as immunodeficiency syndromes and a variety of cancers in both man and animals.  
My recent focus is on studying the viral etiology of human breast and other cancers. The mouse mammary tumor virus (MMTV) is a retrovirus that causes both breast cancer and leukemia in mice. However, it is being increasingly detected in human breast and other cancers such as cancer of the ovaries, endometrium, prostate, skin, and lung. 
There is a lot of controversy as to whether this virus has any role to play in human cancer. My goal is to study systematically how this virus, if at all, may be involved in human breast and perhaps other cancers such as leukemia/lymphomas and eventually what role could it be playing in the induction of these human cancers.  
Additionally, I am interested in the mechanism of MMTV-induced tumors in the host, regulation of basic steps in MMTV replication and gene expression, and role of miRNAs in MMTV-host interactions. Finally, I am interested in how these processes could be modified by steroids and their antagonists as possible future therapeutics since MMTV is a hormone-inducible virus. 
The current research interests include:
Molecular basis of pathogenesis: specifically, the role of MMTV in the induction of human breast and other cancers
Molecular characterization of HIV/AIDS circulating regionally and worldwide
Regulation of gene expression using retroviral model systems  
Selected Publications
Alsuwaidi, A.R., Benedict, S., Kochiyil, J., Mustafa, F., Hartwig, S.M., Almarzooqi, S., Albawardi, A., Rizvi, T.A., Varga, S.M., Souid, A-K. Bioenergetics of murine lungs infected with RSV. Virology J. 10:22. 2013.  
Mustafa, F., Al Amri, D., Al Ali, F., Al Sari, N., Al Suwaidi, S., Jayanth, P., Philips, PS., Rizvi, TA. Sequences within both the 5 UTR and Gag are required for Optimal in vivo Packaging and Propagation of Mouse Mammary Tumor Virus (MMTV) genomic RNA. PLoS ONE 7(10): e47088. doi:10.1371/journal.pone.0047088. 2012.  
Satti, R., Mustafa, F., Imran, M., Haq, T.S., Khan, Z.U., Bilal, I., Zubair, M., Rasool, S.T, Ajmal, M., Qamar, R. Prevalence of Hepatitis C Virus in Urban Ghettos of Twin Cities. Pak J. Zoology 44:937-943. 2012. 
Akhtar N, Niazi M, Mustafa F, Hussain A. A discrete event system specification (DEVS)-based model of consanguinity. J Theor Biol.285:103-12. 2011. 
Siddiqa, A., Niazi, M., Mustafa, F., Bokhari, H., Hussain, A., Akram, N., Shaheen, S., Ahmed, F. and Iqbal, S. A new hybrid agent-based modeling & simulation decision support system for breast cancer data analysis. In: Proc Information and Communication Technologies, pp. 134-139. 2009 
Rizvi, T. A. Ali, J., Phillip, P. S., Ghazawi, A, and Mustafa, F. Role of a Heterologous Retroviral Transport Element in the Development of Genetic Complementation Assay for Mouse Mammary Tumor Virus (MMTV) Replication. Virology 385:464-472. 2009.  
Mustafa, F., Ghazawi, A., Jayanth, P., Phillip, P. S., Ali, J., and Rizvi, T. A. Sequences intervening between the core packaging determinants are dispensable for maintaining the packaging potential and propagation of feline immunodeficiency virus transfer vector RNAs. J. Virol. 79:13817-13821. 2005.  
Mustafa, F., P. Jayanth, P.S. Phillip, A. Ghazawi, R.D. Schmidt, K.A. Lew, and T.A. Rizvi. Relative activity of the FIV promoter in feline and primate cell lines. Microbes Infect. 7:233-239, 2005.  
Mustafa, F., Phillip, P. S., Jayanth, P., Ghazawi, A., Lew, K. A., Schmidt, R. D., and Rizvi, T. A. Close proximity of MPMV CTE to the polyadenylation sequences is important for efficient function in the subgenomic context. Virus Research. 105:209-218. 2004. 
Mustafa, F., K. A, Lew, R. D. Schmidt, M. T. Browning, and T. A. Rizvi. Mutational analysis of the predicted secondary RNA structure of the Mason-Pfizer Monkey Virus packaging signal. Virus Research, 99:35-46. 2004.  
Mustafa, F., S. Bhadra, D. Johnston, M. Lozano, and J. P. Dudley. The type B leukemogenic virus superantigen is dispensable for T-cell lymphomagenesis. J. Virol. 77:3866-70. 2003.  
Schmidt, R. D., F. Mustafa, K. A. Lew, M. T. Browning, and T. A. Rizvi. Sequences within both the 5 untranslated region and the gag gene are important for efficient encapsidation of Mason-Pfizer monkey virus RNA. Virology 309:166-78. 2003.  
Mustafa, F., M. Lozano, and J. P. Dudley. Superantigen function from the C3H MMTV provirus requires a splice donor site in the envelope gene. J. Virol.74:9431-9440, 2000.  
Polack, F. P., S. H. Lee, S. Permar, E. Manyara, H. G. Nousari, Y. Jeng, F. Mustafa, A. Vlasamakis, R. J. Adams, H. L. Robinson, and D. E. Griffin. Successful DNA immunization against measles: Neutralizing antibody against either the hemagglutinin or fusion glycoprotein protects rhesus macaques without evidence of atypical measles. Nature Medicine, 6:776-781, 2000.  
Barnett, A., F. Mustafa, T. J. Wrona, M. Lozano, and J. P. Dudley. Expression of Mouse Mammary Tumor Virus superantigen mRNA in the thymus correlates with kinetics of self-reactive T-cell loss. J. Virol. 73:6634-6645, 1999.  
Lu, S., R. Wyatt, J. F. L. Richmond, F. Mustafa, S. Wang, J. Weng, D. C. Montefiori, J. Sodroski, and H. L. Robinson. Immunogenicity of DNA vaccines expressing human immunodeficiency virus type 1 envelope glycoprotein with and without deletions in the V1/2 and V3 regions. AIDS Res. Hum. Retroviruses 14:151-155, 1998.  
Rappaport, E., C. R. Casella, D. Ikle, F. Mustafa, D. Isaak, and T. H. Finkel. Mapping of HIV-1 determinants of apoptosis in infected T cells. Virology 252:407-417, 1998.  
Yang, K., F. Mustafa, A. Valsamakis, J. C. Santoro, D. E. Griffin, and H. L. Robinson. Early studies on DNA-based immunizations for Measles Virus. Vaccine 15:888-892, 1997.  
Mustafa, F., J. F. L. Richmond, R. F. Larsson, S. Lu, R. Fredricksson, E. M. Fenyo, M. O'Connell, E. Johnson, J. Weng, J. C. Santoro, and H. L. Robinson. HIV-1 Env glycoproteins from two series of patient isolates: Replication phenotype and immunogenicity. Virology 229:269-278, 1997.  
Lu, S. J. Arthos, D. C. Montefiori, Y. Yasutomi, K. Manson, F. Mustafa, E. Johnson, J. C. Santoro, J. Wissink, J. I. Mullins, J. R. Haynes, N. L. Letvin, M. Wyand, and H. L. Robinson.. Simian immunodeficiency virus DNA vaccine trial in macaques. J. Virol. 70:3978-3991, 1996.  
Yasutomi, Y., H. L. Robinson, S. Lu, F. Mustafa, C. Lekutis, J. Arthos, J. I. Mullins, G. Voss, K. Manson, M. Wyand, and N. L. Letvin. Simian immunodeficiency virus-specific cytotoxic T lymphocyte induction through DNA vaccination of rhesus monkeys. J. Virol. 70:678-681, 1996.  
Mustafa, F. and H. L. Robinson. Context-dependent role of human immunodeficiency virus type 1 auxiliary genes in the establishment of chronic virus producers. J. Virol. 67:6909-6915, 1993.  
Mustafa, F., Al Amri, D., Al Ali, F., Al Sari, N., Al Suwaidi, S., Jayanth, P., Philips, PS, Rizvi, TA. Sequences within both the 5 UTR and Gag are Required for Optimal in vivo Packaging and Propagation of Mouse Mammary Tumor Virus (MMTV) genomic RNA. PLoS ONE 7(10): e47088. doi:10.1371/journal.pone.0047088. 2012. 
Al Shamsi, I.R., Al Dhaheri, N.S., Phillip, P.S., Mustafa, F., and Rizvi, T.A. Reciprocal Cross-packaging of Primate Lentiviral (HIV-1 and SIV) RNAs by Heterologous Non-Lentiviral MPMV Proteins. Virus Research 155:352-357. 2011.  
Hassan, A.H., Awad, S., Al-Natour, Z., Othman, S., Mustafa, F., and Rizvi, T. A. Selective recognition of acetylated histones by bromodomains in transcriptional co-activators. Biochem. J. 402:125-133. 2007.  
Browning, M. T., F. Mustafa, R. D. Schmidt, K. A. Lew, and T. A. Rizvi. Sequences within the gag gene of Feline Immunodeficiency Virus (FIV) are important for efficient RNA encapsidation. Virus Research, 93:199-209. 2003.  
Mertz, J., F. Mustafa, S. Meyers, and J. P. Dudley. Type B leukemogenic virus has a T-cell specific enhancer that binds AML-1. J. Virol. 75:2174-2184. 2001.  
Richmond, J. F. L., F. Mustafa, S. Lu, J. C. Santoro, J. Weng, M. O'Connell, E. M. Fenyo, J. L. Hurwitz, D. C. Montefiori, and H. L. Robinson. Screening of HIV-1 Env glycoproteins for the ability to raise neutralizing antibody using DNA immunization and recombinant vaccinia virus boosting. Virology 230:265-274, 1997.  
Rizvi, T.A., Kenyon, J.C., Ali, J., Aktar, S.J., Phillip, P.S., Ghazawi, A., Mustafa, F., and Lever, A.M.L. Optimal packaging of FIV genomic RNA depends upon a conserved long-range interaction and a palindromic sequence within gag. J. Mol. Bio. 403:103119. 2010.  
Ghazawi, A., Mustafa, F., Phillip, P. S., Jayanth, P., Ali, J., and Rizvi, T. A. Both the 5 and 3 LTRs of FIV contain minor RNA encapsidation determinants compared to the two core packaging determinants within the 5 untranslated region and gag. Microbes and Infect. 8:767-778. 2006.  
Browning, M. T., F. Mustafa, R. D. Schmidt, K. A. Lew, and T. A. Rizvi. Delineation of sequences important for FIV RNA encapsidation. J. Gen. Virol. 84: 621-627. 2003.  
Torres, C.A., K. Yang, F. Mustafa, H.L. Robinson. DNA immunization: Effect of secretion of DNA-expressed hemagglutinins on antibody responses. Vaccine 10:805-814, 1999.  
Robinson, H. L., S. Lu, F. Mustafa, E. Johnson, J. C. Santoro, J. Arthos, J. Winsink, J. I. Mullins, D. Montefiori, Y. Yasutomi, N. L. Letvin, J. R. Haynes, K. Manson, and M. Wyand. Simian immunodeficiency virus DNA vaccine trial in macaques. Annals New York Acad. Sci. 772:209-211, 1995.