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Dr. Rajesh Mohanraj
Assistant Professor
Department of Pharmacology and Therapeutics

Phone:	971 3 7137 513
Fax:	971 3 7672033
Email:	rajm@uaeu.ac.ae
College of Medicine and Health Sciences United Arab Emirates University P.O.Box 17666, Al-Ain United Arab Emirates

*Degree*		*University*		*Year*
BSc		University of Madras		1996
MS		BITS, Pilani, India		1999
Ph.D.		BITS, Pilani, India		2004

*Appointment*		*Year*
Assistant Professor - Department of Pharmacology, FMHS, UAE University		May 2011-present
Research Fellow - National Institutes of Health, Bethesda, USA		2006-2011
Postdoctoral Fellow - National University of Singapore		2005-2006
Postdoctoral Fellow - Johns Hopkins University - SOM - Singapore		2003-2005

Research Interest
Role of sphingolipids in diabetic vascular complications and tumor metastasis.
Role of sphingolipids in metabolic syndromes
Molecular mechanisms involved in pathogenesis of diabetic vascular complications.

Selected Publications
Mukhopadhyay P, Rajesh M, Batkai S, Horvath B, Matsumoto S, Saito K, Batkai S, Vivek Patel, Tanashian G, Gao R, Wink DA, Mechoulam R, Hasko G, Pacher P. Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and cell death. Free Radical Biology & Medicine. 2011. 50; 1368-81. [ equally contributed as first author].
Rajesh M, Mukhopadhyay P, Batkai S, Patel V, et al., Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, inflammatory and cell death signaling pathways in diabetic cardiomyopathy. Journal of the American College of Cardiology 2010; 56: 2115-2125.
Mukhopadhyay P* , Rajesh M , Pan H, Patel V, Mukhopadhyay B, Bátkai S, Gao B, Haskó G, Pacher P. Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy. Free Radical Biology & Medicine. 2010; 48:457-467. [ Equally contributed as first author]
Mukhopadhyay P , Rajesh M, Bátkai S, Patel V, Kashiwaya Y, Liaudet L, Evgenov OV, Mackie K, Haskó G, Pacher P. CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes. Cardiovascular Research. 2010; 35:773-784. [* Equally contributed as first author].
Rajesh M, P. Mukhopadhyay, S. Bátkai, B. Mukhopadhyay, V. Patel, G. Haskó, C. Szabó, J. G. Mabley, L. Liaudet, and P. Pacher. Xanthine oxidase inhibitor allopurinol attenuates the development of experimental diabetic cardiomyopathy. Journal of Cellular & Molecular Medicine 2009; 13(8b); 2330-2341.
Rajesh M , P. Mukhopadhyay, G. Hasko, J.W. Huffman, K. Mackie and P. Pacher. CB2 cannabinoid receptor agonists attenuate TNF-α-induced human vascular smooth muscle cell proliferation and Migration. British Journal of Pharmacology, 2008; 153: 347-357.
Rajesh M, P. Mukhopadhyay, S. Batkai, Liauder L, J.W. Huffman, Ungvari Z, K. Mackie, Chatterjee S and P. Pacher. CB2 cannabinoid receptor stimulation attenuates TNF--induced human endothelial cell activation in vitro and vascular inflammation in vivo. American Journal of Physiology Heart and Circulatory Physiology. 2007: 293: H2210-H2018
Rajesh M, Pan H, P. Mukhopadhyay, S. Bátkai, Hyiaman D, G. Hasko, Liaudet L, Gao B and P. Pacher. Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response and apoptosis. Journal of Leukocyte Biology, 2007: 82; 1382-1389, [This article was selected as PIVOTAL ADVANCE with Cover Page Illustration & Editorial Comment].
Rajesh M, A. Kolmakova & S Chatterjee. Novel Role of Lactosylceramide in VEGF Mediated Angiogenesis in Human Endothelial Cells. Circulation Research. 2005; 97: 796-804.
Rajesh M, Mukhopadhyay P, Haskó G, Liaudet L, Mackie K, Pacher P. Cannabinoid -1 receptor activation induces reactive oxygen species-dependent and independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells. British Journal of Pharmacology. 2010; 160: 688-700.
A. Kolmakova , Rajesh M , D. Zang D, R. Pili, S. Chatterjee VEGF recruits Lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo. Glycoconjugate Journal. 2009; 26:547-558 [* equally contributed as first author].
Rajesh M, P. Mukhopadhyay, S. Batkai, G. Hasko, L. Liaudet, V. Drel, I. Obrosova, P. Pacher. Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption. American Journal of Physiology Heart and Circulatory Physiology. 2007: 293; H610-H619
El-Remessey AB , Rajesh M , Mukhopadhyay P, Horvath B, Patel V, Al-Gayar MMH, Pillai B, Pacher P. Cannabinoid 1 receptor activation contributes to the vascular inflammation and cell death in diabetic retinopathy. Diabetalogia. 2011 2011, 54, 1567-1578. [* Equally contributed as first author].