Dr. Rajesh Mohanraj       
       
Assistant Professor
Department of Pharmacology and Therapeutics
Phone: 971 3 7137 513
Fax: 971 3 7672033
Email: rajm@uaeu.ac.ae


College of Medicine and Health Sciences

United Arab Emirates University
P.O.Box 17666, Al-Ain
United Arab Emirates
DegreeUniversityYear
BScUniversity of Madras1996
MSBITS, Pilani, India1999
Ph.D.BITS, Pilani, India2004
AppointmentYear
Assistant Professor - Department of Pharmacology, FMHS, UAE UniversityMay 2011-present
Research Fellow - National Institutes of Health, Bethesda, USA2006-2011
Postdoctoral Fellow - National University of Singapore2005-2006
Postdoctoral Fellow - Johns Hopkins University - SOM - Singapore2003-2005
Research Interest
Role of sphingolipids in diabetic vascular complications and tumor metastasis.  
Role of sphingolipids in metabolic syndromes  
Molecular mechanisms involved in pathogenesis of diabetic vascular complications.  
Selected Publications
Rajesh M, Bátkai S, Kechrid M, Mukhopadhyay P, Lee WS, Horváth B et al., Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy. Diabetes, 2012; 61: 716-27.  
El-Remessey AB *, Rajesh M *, Mukhopadhyay P, Horvath B, Patel V, Al-Gayar MMH, Pillai B, Pacher P. Cannabinoid 1 receptor activation contributes to the vascular inflammation and cell death in diabetic retinopathy. Diabetalogia. 2011 2011, 54, 1567-1578. [* Equally contributed as first author]. 
Mukhopadhyay P*, Rajesh M*, Batkai S*, Horvath B, Matsumoto S, Saito K, Batkai S, Vivek Patel, Tanashian G, Gao R, Wink DA, Mechoulam R, Hasko G, Pacher P. Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and cell death. Free Radical Biology & Medicine. 2011. 50; 1368-81. [* equally contributed as first author]. 
Rajesh M, Mukhopadhyay P, Haskó G, Liaudet L, Mackie K, Pacher P. Cannabinoid -1 receptor activation induces reactive oxygen species-dependent and independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells. British Journal of Pharmacology. 2010; 160: 688-700.  
Rajesh M, Mukhopadhyay P, Batkai S, Patel V, et al., Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, inflammatory and cell death signaling pathways in diabetic cardiomyopathy. Journal of the American College of Cardiology 2010; 56: 2115-2125. 
Mukhopadhyay P *, Rajesh M*, Bátkai S, Patel V, Kashiwaya Y, Liaudet L, Evgenov OV, Mackie K, Haskó G, Pacher P. CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes. Cardiovascular Research. 2010; 35:773-784. [* Equally contributed as first author]. 
Mukhopadhyay P* , Rajesh M *, Pan H, Patel V, Mukhopadhyay B, Bátkai S, Gao B, Haskó G, Pacher P. Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy. Free Radical Biology & Medicine. 2010; 48:457-467. [* Equally contributed as first author] 
A. Kolmakova *, Rajesh M *, D. Zang D, R. Pili, S. Chatterjee VEGF recruits Lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo. Glycoconjugate Journal. 2009; 26:547-558 [* equally contributed as first author]. 
Rajesh M, P. Mukhopadhyay, S. Bátkai, B. Mukhopadhyay, V. Patel, G. Haskó, C. Szabó, J. G. Mabley, L. Liaudet, and P. Pacher. Xanthine oxidase inhibitor allopurinol attenuates the development of experimental diabetic cardiomyopathy. Journal of Cellular & Molecular Medicine 2009; 13(8b); 2330-2341. 
Rajesh M, Pan H, P. Mukhopadhyay, S. Bátkai, Hyiaman D, G. Hasko, Liaudet L, Gao B and P. Pacher. Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response and apoptosis. Journal of Leukocyte Biology, 2007: 82; 1382-1389, [This article was selected as PIVOTAL ADVANCE with Cover Page Illustration & Editorial Comment]. 
Rajesh M, P. Mukhopadhyay, S. Batkai, G. Hasko, L. Liaudet, V. Drel, I. Obrosova, P. Pacher. Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption. American Journal of Physiology Heart and Circulatory Physiology. 2007: 293; H610-H619 
Rajesh M, P. Mukhopadhyay, S. Batkai, Liauder L, J.W. Huffman, Ungvari Z, K. Mackie, Chatterjee S and P. Pacher. CB2 cannabinoid receptor stimulation attenuates TNF--induced human endothelial cell activation in vitro and vascular inflammation in vivo. American Journal of Physiology Heart and Circulatory Physiology. 2007: 293: H2210-H2018  
Rajesh M , P. Mukhopadhyay, G. Hasko, J.W. Huffman, K. Mackie and P. Pacher. CB2 cannabinoid receptor agonists attenuate TNF-α-induced human vascular smooth muscle cell proliferation and Migration. British Journal of Pharmacology, 2008; 153: 347-357. 
Rajesh M, A. Kolmakova & S Chatterjee. Novel Role of Lactosylceramide in VEGF Mediated Angiogenesis in Human Endothelial Cells. Circulation Research. 2005; 97: 796-804.